Selected publications
2020-2022
Modzelewski A, Gan Chong J, Wang T and He L. Mammalian genome innovation through transposon domestication. Nature Cell Biology, in press.
Modzelewski A*, Shao W*, Chen J, Lee A, Qi X, Noon M, Tjokro K, Sales G, Biton A, Speed T, Xuan Z, Wang T#, Risso D# and He L#. A species-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for preimplantation development. Cell, 2021 Oct 28;184(22):5541-5558.e22. Available at bioRxiv, doi: https://doi.org/10.1101/2021.03.24.436683
Xue B, Chuang CH, Prosser HM, Fuziwara CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B#, He L#. miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts. Genes and Development, 2021. Available at bioRxiv 2020.09.02.276550; doi: https://doi.org/10.11.
Elisabet Rosàs-Canyelles*, Andrew J Modzelewski*, Alisha Geldert, Lin He, Amy E Herr. Multimodal detection of protein isoforms and nucleic acids from mouse preimplantation embryos. Nature Protocols , 2021 Feb;16(2):1062-1088. doi: 10.1038/s41596-020-00449-2. Epub 2021 Jan 15.
2017-2019
Chen S., Sun S., Schaffer D., and He L. CRISPR-READI: Efficient generation of knock-in mice by CRISPR RNP Electroporation and AAV Donor Infection. Cell reports, 2019 Jun 25;27(13):3780-3789.e4. doi: 10.1016/j.celrep.2019.05.103.
Modzelewski AJ*, Chen S*, Willis BJ, Lloyd KCK, Wood JA and He L. Efficient mouse genome engineering by CRISPR-EZ technology. Nature Protocols, 2018, Jun;13(6):1253-1274. doi: 10.1038/nprot.2018.012. Epub 2018 May 10.
Li MA#, Amaral PP, Cheung P, Bergmann JH, Kinoshita M, Kalkan T, Ralser M, Robson S, von Meyenn F, Paramor M, Yang F, Chen C, Nichols J, Spector D, Kouzarides T, He L#, Smith A #. A lncRNA fine tunes the dynamics of a cell state transition involving Lin28-let7 and de novo DNA methylation. Elife, 2017, Aug 18;6. pii: e23468. doi: 10.7554/eLife.23468.
Selleri L, Bartolomei MS, Bickmore WA, He L, Stubbs L, Reik W, Barsh GS. A Hox-Embedded Long Noncoding RNA: Is It All Hot Air? PLoS Genetics 2016 Dec 15;12(12):e1006485. doi: 10.1371/journal.pgen.1006485.
Choi YJ*, Lin CP*#, Risso D*, Chen S, Kim TA, Tan M, Li JB, Wu Y, Chen C, Xuan Z, MacFarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L#. Deficiency of miRNA miR-34a expands cell fate potential of pluripotent stem cells. Science, (research article) , 2017 Feb 10;355(6325).
2014-2016
Chen S, Lee B, Lee A, Modzelewski A# and He L#. Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes. J. Biol Chem 2016 May 5. pii: jbc.M116.733154.
Olive V, Sabio E, Minella AC and He L. Outside the coding genome, microRNAs make a big difference. Science Signaling, Sci Signal. 2015 Mar 17;8(368):re2.
Song R*#, Walentek P*, Sponer N*, Lize M, Klimke A, Lee JS, Dixon GR, Lishko P, Kessel M, He L#. miR-34/449 miRNAs are required for motile ciliogenesis by repressing Cp110. Nature (Research article), 2014 Jun 5;510(7503):115-20.
Krzeszinski JY, Wei W, Huynh H, Jin Z, Chang T, Xie X, He L, Lingegowda MS, Lopez-Berestein G, Sood AK, Mendell JT and Wan Y. MiR-34a blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2. Nature, 2014 Aug 28;512(7515):431-5.
Xue B and He L. An expanding universe of the non-coding genome in cancer biology. Carcinogenesis, 2014 Jun;35(6):1209-1216. Epub 2014 Apr 18.
Okada N, Ribeiro M, Biton A, Lin C, Lai G, Bu P, Vogel H, Jablons DM , Keller A, Wilkinson JE, He B, Speed TP and He L. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression Genes and Development, 2014 Mar 1;28(5):438-50. doi: 10.1101/gad.233585.113.
2008-2013
Olive V*, Sabio E*, Bennett M, De Jong C, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig M, Goga A, Speed TP, Xuan Z, Evan G, Wan Y, Minella A, He L. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife. 2013 Oct 15;2:e00822. doi: 10.7554/eLife.00822. PMID: 24137534
Lin C, Choi Y, Hicks GG and He L. The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle, 2012 Jun 1;11(11). PMID: 22580472.
Choi Y*, Lin C*, Zhong Y, He X, Kim S, Okada N, Bu P, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ, and He L. miR-34a miRNA provides a barrier for somatic cell reprogramming. Nature Cell Biology, 2011 Oct 23;13(11):1353-60. PMID: 22020437.
He L. Post-transcriptional regulation of PTEN dosage by non-coding RNAs. Science Signaling 2010 Nov 2;3(146):pe39. PMID: 21045203.
Olive V *, Bennett MJ*, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li Q, Lowe SW, Hannon GJ# and He L#. miR-19 is a key oncogenic component of mir-17-92. Genes and Development 2009 Dec 15;23(24):2839-49. PMID: 20008935.
2003-2007
He L, He X, Lowe SW and Hannon GJ. microRNAs join the p53 pathway, another piece of the tumor suppressor puzzle. Nat Rev Cancer. 2007 Nov;7(11):819-22.
He L*, He X*, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA# and Hannon GJ#. A microRNA component of the p53 tumour suppressor network. Nature. 2007 Jun 28;447(7148):1130-4.
He L*, Thomson JM*, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ# and Hammond SM#. A microRNA polycistron as a potential human oncogene. Nature. 2005 Jun9; 435(7043):828-33.
He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004 Jul;5(7):522-31.
1998-2003
He L, Eldredge AG, Jackson PK, Gunn TM, Barsh GS. Accessory proteins for melanocortin signaling: attractin and mahogunin. Ann N Y Acad Sci. 2003 Jun;994:288-98.
He L, Lu XY, Jolly AF, Eldridge AG, Watson SJ, Jackson PK, Barsh GS# and Gunn TM#. Spongiform encephalopathy caused by defects of an E3 ubiquitin ligase in mahoganoid mice. Science, 2003 Jan 31;299(5607):710-2.
He L*, Gunn TM*, Bouley DM, Lu XY, Watson SJ, Schlossman SF, Duke-Cohan JS, Barsh GS. A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet. 2001 Jan;27(1):40-7.
Gunn TM, Miller KA, He L, Hyman RW, Davis RW, Azarani A, Schlossman SF, Duke-Cohan JS, Barsh GS. The mouse mahogany locus encodes a transmembrane form of human attractin. Nature 1999 Mar 11;398(6723):152-6.
2020-2022
Modzelewski A, Gan Chong J, Wang T and He L. Mammalian genome innovation through transposon domestication. Nature Cell Biology, in press.
Modzelewski A*, Shao W*, Chen J, Lee A, Qi X, Noon M, Tjokro K, Sales G, Biton A, Speed T, Xuan Z, Wang T#, Risso D# and He L#. A species-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for preimplantation development. Cell, 2021 Oct 28;184(22):5541-5558.e22. Available at bioRxiv, doi: https://doi.org/10.1101/2021.03.24.436683
Xue B, Chuang CH, Prosser HM, Fuziwara CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B#, He L#. miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts. Genes and Development, 2021. Available at bioRxiv 2020.09.02.276550; doi: https://doi.org/10.11.
Elisabet Rosàs-Canyelles*, Andrew J Modzelewski*, Alisha Geldert, Lin He, Amy E Herr. Multimodal detection of protein isoforms and nucleic acids from mouse preimplantation embryos. Nature Protocols , 2021 Feb;16(2):1062-1088. doi: 10.1038/s41596-020-00449-2. Epub 2021 Jan 15.
2017-2019
Chen S., Sun S., Schaffer D., and He L. CRISPR-READI: Efficient generation of knock-in mice by CRISPR RNP Electroporation and AAV Donor Infection. Cell reports, 2019 Jun 25;27(13):3780-3789.e4. doi: 10.1016/j.celrep.2019.05.103.
Modzelewski AJ*, Chen S*, Willis BJ, Lloyd KCK, Wood JA and He L. Efficient mouse genome engineering by CRISPR-EZ technology. Nature Protocols, 2018, Jun;13(6):1253-1274. doi: 10.1038/nprot.2018.012. Epub 2018 May 10.
Li MA#, Amaral PP, Cheung P, Bergmann JH, Kinoshita M, Kalkan T, Ralser M, Robson S, von Meyenn F, Paramor M, Yang F, Chen C, Nichols J, Spector D, Kouzarides T, He L#, Smith A #. A lncRNA fine tunes the dynamics of a cell state transition involving Lin28-let7 and de novo DNA methylation. Elife, 2017, Aug 18;6. pii: e23468. doi: 10.7554/eLife.23468.
Selleri L, Bartolomei MS, Bickmore WA, He L, Stubbs L, Reik W, Barsh GS. A Hox-Embedded Long Noncoding RNA: Is It All Hot Air? PLoS Genetics 2016 Dec 15;12(12):e1006485. doi: 10.1371/journal.pgen.1006485.
Choi YJ*, Lin CP*#, Risso D*, Chen S, Kim TA, Tan M, Li JB, Wu Y, Chen C, Xuan Z, MacFarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L#. Deficiency of miRNA miR-34a expands cell fate potential of pluripotent stem cells. Science, (research article) , 2017 Feb 10;355(6325).
2014-2016
Chen S, Lee B, Lee A, Modzelewski A# and He L#. Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes. J. Biol Chem 2016 May 5. pii: jbc.M116.733154.
Olive V, Sabio E, Minella AC and He L. Outside the coding genome, microRNAs make a big difference. Science Signaling, Sci Signal. 2015 Mar 17;8(368):re2.
Song R*#, Walentek P*, Sponer N*, Lize M, Klimke A, Lee JS, Dixon GR, Lishko P, Kessel M, He L#. miR-34/449 miRNAs are required for motile ciliogenesis by repressing Cp110. Nature (Research article), 2014 Jun 5;510(7503):115-20.
Krzeszinski JY, Wei W, Huynh H, Jin Z, Chang T, Xie X, He L, Lingegowda MS, Lopez-Berestein G, Sood AK, Mendell JT and Wan Y. MiR-34a blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2. Nature, 2014 Aug 28;512(7515):431-5.
Xue B and He L. An expanding universe of the non-coding genome in cancer biology. Carcinogenesis, 2014 Jun;35(6):1209-1216. Epub 2014 Apr 18.
Okada N, Ribeiro M, Biton A, Lin C, Lai G, Bu P, Vogel H, Jablons DM , Keller A, Wilkinson JE, He B, Speed TP and He L. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression Genes and Development, 2014 Mar 1;28(5):438-50. doi: 10.1101/gad.233585.113.
2008-2013
Olive V*, Sabio E*, Bennett M, De Jong C, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig M, Goga A, Speed TP, Xuan Z, Evan G, Wan Y, Minella A, He L. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife. 2013 Oct 15;2:e00822. doi: 10.7554/eLife.00822. PMID: 24137534
Lin C, Choi Y, Hicks GG and He L. The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle, 2012 Jun 1;11(11). PMID: 22580472.
Choi Y*, Lin C*, Zhong Y, He X, Kim S, Okada N, Bu P, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ, and He L. miR-34a miRNA provides a barrier for somatic cell reprogramming. Nature Cell Biology, 2011 Oct 23;13(11):1353-60. PMID: 22020437.
He L. Post-transcriptional regulation of PTEN dosage by non-coding RNAs. Science Signaling 2010 Nov 2;3(146):pe39. PMID: 21045203.
Olive V *, Bennett MJ*, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li Q, Lowe SW, Hannon GJ# and He L#. miR-19 is a key oncogenic component of mir-17-92. Genes and Development 2009 Dec 15;23(24):2839-49. PMID: 20008935.
2003-2007
He L, He X, Lowe SW and Hannon GJ. microRNAs join the p53 pathway, another piece of the tumor suppressor puzzle. Nat Rev Cancer. 2007 Nov;7(11):819-22.
He L*, He X*, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA# and Hannon GJ#. A microRNA component of the p53 tumour suppressor network. Nature. 2007 Jun 28;447(7148):1130-4.
He L*, Thomson JM*, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ# and Hammond SM#. A microRNA polycistron as a potential human oncogene. Nature. 2005 Jun9; 435(7043):828-33.
He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004 Jul;5(7):522-31.
1998-2003
He L, Eldredge AG, Jackson PK, Gunn TM, Barsh GS. Accessory proteins for melanocortin signaling: attractin and mahogunin. Ann N Y Acad Sci. 2003 Jun;994:288-98.
He L, Lu XY, Jolly AF, Eldridge AG, Watson SJ, Jackson PK, Barsh GS# and Gunn TM#. Spongiform encephalopathy caused by defects of an E3 ubiquitin ligase in mahoganoid mice. Science, 2003 Jan 31;299(5607):710-2.
He L*, Gunn TM*, Bouley DM, Lu XY, Watson SJ, Schlossman SF, Duke-Cohan JS, Barsh GS. A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet. 2001 Jan;27(1):40-7.
Gunn TM, Miller KA, He L, Hyman RW, Davis RW, Azarani A, Schlossman SF, Duke-Cohan JS, Barsh GS. The mouse mahogany locus encodes a transmembrane form of human attractin. Nature 1999 Mar 11;398(6723):152-6.